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Non-negativematrix factorization based unmixing for principal component transformed hyperspectral data

Xiu-rui GENG,Lu-yan JI,Kang SUN

《信息与电子工程前沿（英文）》 2016年 第17卷 第5期   页码 403-412 doi: 10.1631/FITEE.1600028

摘要： Non-negative matrix factorization (NMF) has been widely used in mixture analysis for hyperspectral remote sensing. When used for spectral unmixing analysis, however, it has two main shortcomings: (1) since the dimensionality of hyperspectral data is usually very large, NMF tends to suffer from large computational complexity for the popular multiplicative iteration rule; (2) NMF is sensitive to noise (outliers), and thus the corrupted data will make the results of NMF meaningless. Although principal component analysis (PCA) can be used to mitigate these two problems, the transformed data will contain negative numbers, hindering the direct use of the multiplicative iteration rule of NMF. In this paper, we analyze the impact of PCA on NMF, and find that multiplicative NMF can also be applicable to data after principal component transformation. Based on this conclusion, we present a method to perform NMF in the principal component space, named ‘principal component NMF’ (PCNMF). Experimental results show that PCNMF is both accurate and time-saving.

关键词： Non-negative matrix factorization (NMF)     Principal component analysis (PCA)     Endmember     Hyperspectral    

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鸡尾酒会问题的技术回顾、当前进展及未来挑战 Review

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿（英文）》 2018年 第19卷 第1期   页码 40-63 doi: 10.1631/FITEE.1700814

摘要： 介绍了以下内容：传统的单通道情况下的技术，如计算听觉场景分析（computational auditory scene analysis, CASA）、非负矩阵分解（non-negative matrixfactorization, NMF）以及生成式模型建模；传统的多通道情况下的技术，如波束成形和多通道盲源分离；一些基于深度学习的最新技术，如深度聚类（deep clustering, DPCL）、深度吸引网络

关键词： 鸡尾酒会问题；计算听觉场景分析；非负矩阵分解；排列不变性训练；多说话人语音处理    

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Organophosphate esters in sediment from Taihu Lake, China: Bridging the gap between riverine sources and lake sinks

《环境科学与工程前沿（英文）》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1464-9

摘要：

• Eleven OPEs were detected in river sediment and lake sediment in Taihu Lake.

关键词： Organophosphate esters     Partition     Vertical distribution     Composition profile     Positive matrix factorization    

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Characterization of submicron aerosols in the urban outflow of the central Pearl River Delta region of China

Zhaoheng GONG, Zijuan LAN, Lian XUE, Liwu ZENG, Lingyan HE, Xiaofeng HUANG

《环境科学与工程前沿（英文）》 2012年 第6卷 第5期   页码 725-733 doi: 10.1007/s11783-012-0441-8

摘要： Submicron aerosol particles (with aerodynamic diameters less than 1 μm, PM ) were sampled and measured in Heshan, an urban outflow site of Guangzhou megacity in Pearl River Delta in South China, using an Aerodyne High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) in November 2010 during 2010 Guangzhou Asian Games. The mean PM mass concentration measured was 47.9±17.0 μg·m during the campaign, with organic aerosol (OA) and sulfate being the two dominant species, accounting for 36.3% and 20.9% of the total mass, respectively, followed by black carbon (17.1%, measured by an aethalometer), nitrate (12.9%), ammonium (9.6%) and chloride (3.1%). The average size distributions of the species (except black carbon) were dominated by an accumulation mode peaking at ~550 nm. Calculations based on high-resolution organic mass spectrum showed that, C, H, O and N on average contributed 58.1%, 7.3%, 30.7%, and 3.9% to the total organic mass, respectively. The average ratio of organic mass over organic carbon mass (OM/OC) was 1.73±0.08. Four components of OA were identified by the Positive Matrix Factorization (PMF) analysis, including a hydrocarbon-like (HOA), a biomass burning (BBOA) and two oxygenated (SV-OOA and LV-OOA) organic aerosol components, which on average accounted for 18.0%, 14.3%, 28.8% and 38.9% of the total organic mass, respectively.

关键词： organic aerosol     high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS)     positive matrix factorization    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

《医学前沿（英文）》 doi: 10.1007/s11684-023-1016-8

摘要： p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010). In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective response rate (ORR) of 42% in 12 patients with stage IV TNBC. Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53. In a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53. In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and the most responsive patient with TNBC. Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Eco-innovative design approach: Integrating quality and environmental aspects in prioritizing and solving engineering problems

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 203-217 doi: 10.1007/s11465-014-0308-8

摘要：

This study proposes an eco-innovative design process taking into consideration quality and environmental aspects in prioritizing and solving technical engineering problems. This approach provides a synergy between the Life Cycle Assessment (LCA), the non-quality matrix, the Theory of Inventive Problem Solving (TRIZ), morphological analysis and the Analytical Hierarchy Process (AHP). In the sequence of these tools, LCA assesses the environmental impacts generated by the system. Then, for a better consideration of environmental aspects, a new tool is developed, the non-quality matrix, which defines the problem to be solved first from an environmental point of view. The TRIZ method allows the generation of new concepts and contradiction resolution. Then, the morphological analysis offers the possibility of extending the search space of solutions in a design problem in a systematic way. Finally, the AHP identifies the promising solution(s) by providing a clear logic for the choice made. Their usefulness has been demonstrated through their application to a case study involving a centrifugal spreader with spinning discs.

关键词： eco-innovation     non-quality matrix     TRIZ     composted product spreading    

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负能量问题——超光速研究的重要方向

黄志洵

《中国工程科学》 2001年 第3卷 第7期   页码 42-47

摘要：

论述了关于负能量的多个理论预期和相关实验，阐明了超光速研究和负能量概念的关系。

关键词： 负能量     超光速     Casimir效应     消失模     负折射率    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

《医学前沿（英文）》 2021年 第15卷 第1期   页码 1-10 doi: 10.1007/s11684-020-0741-5

摘要： Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

关键词： triple-negative breast cancer     immunotherapy     targeted therapy    

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基于个性化主题模型的用户生成内容推荐 Article

Wei ZHANG, Jia-yu ZHUANG, Xi YONG, Jian-kou LI, Wei CHEN, Zhe-min LI

《信息与电子工程前沿（英文）》 2017年 第18卷 第5期   页码 708-718 doi: 10.1631/FITEE.1500402

摘要： 互联网服务中有很多用户生成的内容（User-generated content, UGC），例如博客，微博等。在这些系统中，需要推荐算法来帮助用户过滤海量的内容。然而，传统的推荐模型没有考虑用户和内容之间的创作关系。本文中，我们验证了：通过引入创作关系信息，可以显著提高推荐算法的各项指标。基于层次主题模型和矩阵分解模型，我们构造了一个新的推荐模型。实验证明我们的新模型显著的优于其它已有模型，并且可以为用户和内容对应的主题给出直观解释。另外，由于从用户生成的内容我们可以推测其兴趣偏好，因此可以解决冷启动问题。

关键词： 用户生成内容；协同过滤；矩阵分解；层次主题模型    

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Fast implementation of kernel simplex volume analysis based on modified Cholesky factorization for endmember

Jing LI,Xiao-run LI,Li-jiao WANG,Liao-ying ZHAO

《信息与电子工程前沿（英文）》 2016年 第17卷 第3期   页码 250-257 doi: 10.1631/FITEE.1500244

摘要： Endmember extraction is a key step in the hyperspectral image analysis process. The kernel new simplex growing algorithm (KNSGA), recently developed as a nonlinear alternative to the simplex growing algorithm (SGA), has proven a promising endmember extraction technique. However, KNSGA still suffers from two issues limiting its application. First, its random initialization leads to inconsistency in final results; second, excessive computation is caused by the iterations of a simplex volume calculation. To solve the first issue, the spatial pixel purity index (SPPI) method is used in this study to extract the first endmember, eliminating the initialization dependence. A novel approach tackles the second issue by initially using a modified Cholesky factorization to decompose the volume matrix into triangular matrices, in order to avoid directly computing the determinant tautologically in the simplex volume formula. Theoretical analysis and experiments on both simulated and real spectral data demonstrate that the proposed algorithm significantly reduces computational complexity, and runs faster than the original algorithm.

关键词： Endmember extraction     Modified Cholesky factorization     Spatial pixel purity index (SPPI)     New simplex growing algorithm (NSGA)     Kernel new simplex growing algorithm (KNSGA)    

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Decellularized extracellular matrix mediates tissue construction and regeneration

《医学前沿（英文）》 2022年 第16卷 第1期   页码 56-82 doi: 10.1007/s11684-021-0900-3

摘要： Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D) structural integrity and cellular-function regulation. Containing the crucial traits of the cellular microenvironment, ECM substitutes mediate cell–matrix interactions to prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissue regeneration in vivo. However, these ECMs are often applied generically and have yet to be extensively developed for specific cell types in 3D cultures. Cultured cells also produce rich ECM, particularly stromal cells. Cellular ECM improves 3D culture development in vitro and tissue remodeling during wound healing after implantation into the host as well. Gaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction or organ regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D organoid culture and tissue remodeling for in vivo regeneration. Overall, the decellularization methodologies and tissue/cell-derived ECM as scaffolds or cellular-growth supplements used in cell propagation and differentiation for 3D tissue culture in vitro are discussed. Moreover, current preclinical applications by which ECM components modulate the wound-healing process are reviewed.

关键词： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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Perspective of mixed matrix membranes for carbon capture

Shinji Kanehashi, Colin A. Scholes

《化学科学与工程前沿（英文）》 2020年 第14卷 第3期   页码 460-469 doi: 10.1007/s11705-019-1881-5

摘要： Polymeric membrane-based gas separation has found wide applications in industry, such as carbon capture, hydrogen recovery, natural gas sweetening, as well as oxygen enrichment. Commercial gas separation membranes are required to have high gas permeability and selectivity, while being cost-effective to process. Mixed matrix membranes (MMMs) have a composite structure that consists of polymers and fillers, therefore featuring the advantages of both materials. Much effort has been made to improve the gas separation performance of MMMs as well as general membrane properties, such as mechanical strength and thermal stability. This perspective describes potential use of MMMs for carbon capture applications, explores their limitations in fabrication and methods to overcome them, and addresses their performance under industry gas conditions.

关键词： membranes     polymeric     mixed matrix     impurities    

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Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

《结构与土木工程前沿（英文）》 2022年 第16卷 第6期   页码 744-761 doi: 10.1007/s11709-022-0843-z

摘要： Improving the cracking resistance of steel-normal concrete (NC) composite beams in the negative moment region is one of the main tasks in designing continuous composite beam (CCB) bridges due to the low tensile strength of the NC deck at pier supports. This study proposed an innovative structural configuration for the negative bending moment region in a steel-concrete CCB bridge with the aid of ultrahigh performance concrete (UHPC) layer. In order to investigate the feasibility and effectiveness of this new UHPC jointed structure in the negative bending moment region, field load testing was conducted on a newly built full-scale bridge. The newly designed structural configuration was described in detail regarding the structural characteristics (cracking resistance, economy, durability, and constructability). In the field investigation, strains on the surface of the concrete bridge deck, rebar, and steel beam in the negative bending moment region, as well as mid-span deflection, were measured under different load cases. Also, a finite element model for the four-span superstructure of the full-scale bridge was established and validated by the field test results. The simulated results in terms of strains and mid-span deflection showed moderate consistency with the test results. This field test and the finite element model results demonstrated that the new configuration with the UHPC layer provided an effective alternative for the negative bending moment region of the composite beam.

关键词： field test     steel-concrete composite beam     continuous girder bridge     negative bending moment region     ultrahigh performance concrete    

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

《医学前沿（英文）》 2021年 第15卷 第4期   页码 621-628 doi: 10.1007/s11684-020-0738-0

摘要： Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

关键词： early breast cancer     21-gene assay     recurrence score     prognosis    

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硅微z轴谐振陀螺仪负电刚度效应分析及实验验证

夏敦柱,周百令,王寿荣

《中国工程科学》 2007年 第9卷 第8期   页码 66-68

摘要：

介绍了在开环工作状态下硅微z轴谐振陀螺仪由于加工工艺缺陷所导致的误差机理。为减小陀螺仪初始电容差和抑制正交耦合误差，提出了一种闭环控制检测策略。重点分析了其力矩反馈器的电刚度效应并给出其线性数学模型表示式。通过对硅微z轴陀螺仪敏感模态的反馈力与谐振频率的关系分析，间接得出了在敏感方向上电负刚度与力矩器所施电压的内在联系，并在实验上进一步验证电刚度效应。这将为下一步闭环控制方案的设计奠定重要基础。

关键词： 硅微z轴陀螺仪     负电刚度     力矩反馈器     微机电系统    

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标题 作者 时间 类型 操作

Non-negativematrix factorization based unmixing for principal component transformed hyperspectral data

Xiu-rui GENG,Lu-yan JI,Kang SUN

期刊论文

鸡尾酒会问题的技术回顾、当前进展及未来挑战

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

期刊论文

Organophosphate esters in sediment from Taihu Lake, China: Bridging the gap between riverine sources and lake sinks

期刊论文

Characterization of submicron aerosols in the urban outflow of the central Pearl River Delta region of China

Zhaoheng GONG, Zijuan LAN, Lian XUE, Liwu ZENG, Lingyan HE, Xiaofeng HUANG

期刊论文

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

期刊论文

Eco-innovative design approach: Integrating quality and environmental aspects in prioritizing and solving engineering problems

null

期刊论文

负能量问题——超光速研究的重要方向

黄志洵

期刊论文

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

期刊论文

基于个性化主题模型的用户生成内容推荐

Wei ZHANG, Jia-yu ZHUANG, Xi YONG, Jian-kou LI, Wei CHEN, Zhe-min LI

期刊论文

Fast implementation of kernel simplex volume analysis based on modified Cholesky factorization for endmember

Jing LI,Xiao-run LI,Li-jiao WANG,Liao-ying ZHAO

期刊论文

Decellularized extracellular matrix mediates tissue construction and regeneration

期刊论文

Perspective of mixed matrix membranes for carbon capture

Shinji Kanehashi, Colin A. Scholes

期刊论文

Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

期刊论文

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

期刊论文

硅微z轴谐振陀螺仪负电刚度效应分析及实验验证

夏敦柱,周百令,王寿荣

期刊论文